Assessing the role of copy number variants in prostate cancer risk and progression using a novel genome-wide screening method W81XWH-09-1-0694
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XWH - 09 - 1 - 0694 TITLE : Assessing the role of copy number variants in prostate cancer risk and progression using a novel genome - wide screening method
Objective: Two recent studies have reported novel heritable copy number variants on chromosomes 2p, 15q, and 12q to be associatedwith prostate cancer (PCa) risk in non-Hispanic Caucasians. The goal of this study was to determine whether these findings could beindependently confirmed in the Caucasian population from the South Texas area.Methods and materials: The study subjects consi...
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The nature and pace of genome mutation is largely unknown. Standard methods to investigate DNA-mutation rely on arraying or sequencing DNA from a population of cells, hence the genetic composition of individual cells is lost and de novo mutation in cell(s) is concealed within the bulk signal. We developed methods based on (SNP-) arraying and next-generation sequencing of single-cell whole-genom...
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BACKGROUND Numerous germline genetic variants are associated with prostate cancer risk, but their biologic role is not well understood. One possibility is that these variants influence gene expression in prostate tissue. We therefore examined the association of prostate cancer risk variants with the expression of genes nearby and genome-wide. METHODS We generated mRNA expression data for 20,2...
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s: Singareddy R, St. John J and Chinni, SR. Molecular characterization of ERG mediated CXCR4 transcriptional regulation. 102end annual American Association for Cancer Research. Orlando, FL. April 2-6, 2011. Chinni, SR. Singareddy R, and St. John J. Role of ERG and CXCR4 in prostate cancer progression. Innovative Minds in Prostate Cancer Today. Orlando, FL. March 912, 2011. Podium Presentation: ...
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Background: Prostate cancer is the second form of cancer among men worldwide. For early cancer detection, we should identify tumors in initial stages before the physical signs become visible. The present study aims to evaluate the diagnostic value of cell-free DNA (cfDNA), its comparison with prostate-specific antigen (PSA) level in prostate cancer screening and also in patients with localized ...
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تاریخ انتشار 2010